(19)

(11)

EP 1 844 062 A2

(12)

(88) Date of publication A3: 15.02.2007 (43) Date of publication: 17.10.2007 Bulletin 2007/42 (21) Application number: 06718809.4 (22) Date of filing: 18.01.2006

(51) International Patent Classification (IPC):  C07H 19/16(2006.01) A61K 31/7076(2006.01) A61P 35/02(2006.01) (86) International application number: PCT/US2006/001791 (87) International publication number: WO 2006/078752 (27.07.2006 Gazette 2006/30)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK YU (30) Priority: 21.01.2005 US 646156 P (71) Applicant: Methylgene, Inc. Saint-Laurent, Quebec H4S 2A1 (CA)

(72) Inventors: WAHHAB, Amal Laval, Quebec H7W 4E1 (CA) BESTERMAN, Jeffrey, M. Baie D'Urfe, Quebec H9X 3V3 (CA) DELORME, Daniel St-Lazare, Quebec J7T 2B2 (CA) ISAKOVIC, Ljubomir Montreal, Quebec H3H 1H4 (CA) LLEWELLYN, David Vancouver, British Columbia V6H 1L6 (CA) RAHIL, Jubrail Montreal, Quebec H9G 2A6 (CA) SAAVEDRA, Oscar Outremont, Quebec H2V 3N2 (CA) DEZIEL, Robert Mount-Royal, Quebec H3R 1W9 (CA) (74) Representative: Mallalieu, Catherine Louise et al D Young & Co 120 Holborn GB-London EC1N 2DY GB-London EC1N 2DY (GB)