(19)

(11)

EP 1 844 148 A2

(12)

(88) Date of publication A3: 01.03.2007 (43) Date of publication: 17.10.2007 Bulletin 2007/42 (21) Application number: 06734091.9 (22) Date of filing: 31.01.2006

(51) International Patent Classification (IPC):  C12N 15/11(2006.01) A61K 31/713(2006.01) C12N 15/864(2006.01) (86) International application number: PCT/US2006/003298 (87) International publication number: WO 2006/083800 (10.08.2006 Gazette 2006/32)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 31.01.2005 US 48627 (71) Applicant: University of Iowa Research Foundation Iowa City, IA 52242-5500 (US)	(72) Inventors: DAVIDSON, Beverly, L. North Liberty, IA 52242 (US) HARPER, Scott Powell, OH 43065 (US) (74) Representative: Maschio, Antonio  D Young & Co 120 Holborn London EC1N 2DY London EC1N 2DY (GB)