(19)

(11)

EP 1 844 158 A2

(12)

(43) Date of publication: 17.10.2007 Bulletin 2007/42 (21) Application number: 05853365.4 (22) Date of filing: 06.12.2005

(51) International Patent Classification (IPC):  C12Q 1/68(2006.01) (86) International application number: PCT/US2005/044423 (87) International publication number: WO 2006/063133 (15.06.2006 Gazette 2006/24)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK YU (30) Priority: 06.12.2004 US 633662 P (71) Applicant: THE JOHNS-HOPKINS UNIVERSITY Baltimore, MD 21218 (US)	(72) Inventors: SHUKTI, Chakravarti Lutherville, MD 21093 (US) WU, Feng Lutherville, MD 21093 (US) (74) Representative: Johansen, Marianne  Albihns A/S, H.C. Andersens Boulevard 49 1553 Copenhagen V 1553 Copenhagen V (DK)