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EP 1 848 454 A1

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(43) Date of publication: 31.10.2007 Bulletin 2007/44 (21) Application number: 06720825.6 (22) Date of filing: 14.02.2006

(51) International Patent Classification (IPC):  A61K 38/20(2006.01) A61K 31/675(2006.01) A61K 31/475(2006.01) A61P 35/00(2006.01) A61K 39/395(2006.01) A61K 31/704(2006.01) A61K 31/573(2006.01) (86) International application number: PCT/US2006/005536 (87) International publication number: WO 2006/089064 (24.08.2006 Gazette 2006/34)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 15.02.2005 US 653233 P 14.04.2005 US 671376 P (71) Applicant: Novartis Vaccines and Diagnostics, Inc. Emeryville, CA 94662-8097 (US)

(72) Inventors: DENIS-MIZE, Kimberly, c/o Chiron Corporation Emeryville, CA 94608 (US) HEISE, Carla, c/o Chiron Corporation Emeryville, CA 94608 (US) MENEZES, Daniel, c/o Chiron Corporation Emeryville, CA 94608 (US) WILSON, Susan E., c/o Chiron Corporation Emeryville, CA 94608 (US) (74) Representative: Marshall, Cameron John et al Carpmaels & Ransford 43-45 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)