(19)

(11)

EP 1 848 506 A2

(12)

(88) Date of publication A3: 25.01.2007 (43) Date of publication: 31.10.2007 Bulletin 2007/44 (21) Application number: 06748243.0 (22) Date of filing: 21.02.2006

(51) International Patent Classification (IPC):  A61P 35/00(2006.01) A61K 31/554(2006.01) A61K 31/495(2006.01) C07D 243/00(2006.01) C07D 498/00(2006.01) A61K 31/553(2006.01) A61K 31/55(2006.01) A61K 31/50(2006.01) C07D 487/00(2006.01) C07D 513/00(2006.01) (86) International application number: PCT/US2006/006303 (87) International publication number: WO 2006/089298 (24.08.2006 Gazette 2006/34)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 18.02.2005 US 654606 P (71) Applicants: Attenuon, LLC San Diego, CA 92121 (US) Changchun Discovery Sciences, Ltd. Changchun, Jilin 130012 (CN)	(72) Inventors: BAI, Xu Bai Carlsbad, California 92009 (US) DANG, Qun San Diego, California 92130 (US) TERNANSKY, Robert, J. Ternansky San Diego, California 92130 (US) (74) Representative: Jones Day  Rechtsanwälte, Attorneys-at-Law, Patentanwälte Prinzregentenstrasse 11 80538 München 80538 München (DE)