AN EFFICIENT AND STEREOSELECTIVE PROCESS FOR LARGE SCALE SYNTHESIS OF 3-(R)-3- (2,3-DIHYDROBENZOFURAN-5-YL)-1,2,3,4- TETRAHYDROPYRROLO{3,4-B}QUINOLIN-9-ONE - Patent 1851227

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EP 1 851 227 A1

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(43)	Date of publication:
	07.11.2007 Bulletin 2007/45

(21)	Application number: 06735630.3

(22)	Date of filing: 21.02.2006

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International Patent Classification (IPC):

C07D 491/04^(2006.01)

A61K 31/437^(2006.01)

(86)	International application number:
	PCT/US2006/006061

(87)	International publication number:
	WO 2006/093719 (08.09.2006 Gazette 2006/36)

(84)	Designated Contracting States:
	AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

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Priority:

25.02.2005 US 656353 P
29.03.2005 US 665954 P

(71)	Applicant: Janssen Pharmaceutica NV
	2340 Beerse (BE)

(72)	Inventors:
	LI, Xun New Hope, Pennsylvania 18938 (US) LEMAIRE, Sebastien B-1348 Louvain-Ia-Neuve (BE) MARKO, Istvan B-1390 Grez-doiceau (BE) WILLEMSENS, Albert B-2340 Beerse (BE)

(74)	Representative: James, Anthony Christopher W.P. et al
	Carpmaels & Ransford 43-45 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)

(54)	AN EFFICIENT AND STEREOSELECTIVE PROCESS FOR LARGE SCALE SYNTHESIS OF 3-(R)-3- (2,3-DIHYDROBENZOFURAN-5-YL)-1,2,3,4- TETRAHYDROPYRROLO{3,4-B}QUINOLIN-9-ONE