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(11)

EP 1 851 244 A1

(12)

(43) Date of publication: 07.11.2007 Bulletin 2007/45 (21) Application number: 05723079.9 (22) Date of filing: 15.02.2005

(51) International Patent Classification (IPC):  C07K 16/00(2006.01) C12P 21/00(2006.01) A61K 39/395(2006.01) (86) International application number: PCT/US2005/004739 (87) International publication number: WO 2006/088447 (24.08.2006 Gazette 2006/34)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR (71) Applicant: GTC Biotherapeutics, Inc. Framingham, MA 01702 (US)	(72) Inventors: STROME, Scott, E. Rochester, MN 55902 (US) SCHINDLER, Daniel Newton Upper Falls, MA 02464 (US) CHEN, Lieping Sparks Glencoe, MD 21152 (US) MEADE, Harry Newton, MA (US) (74) Representative: Williams, Gareth Owen  Marks & Clerk 66-68 Hills Road Cambridge CB2 1LA Cambridge CB2 1LA (GB)