(19)

(11)

EP 1 851 309 A2

(12)

(88) Date of publication A3: 21.06.2007 (43) Date of publication: 07.11.2007 Bulletin 2007/45 (21) Application number: 06708501.9 (22) Date of filing: 24.02.2006

(51) International Patent Classification (IPC):  C12N 9/10(2006.01) C12N 1/21(2006.01) C12N 15/54(2006.01) C12P 37/00(2006.01) (86) International application number: PCT/EP2006/060256 (87) International publication number: WO 2006/089946 (31.08.2006 Gazette 2006/35)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK YU (30) Priority: 24.02.2005 EP 05101423 (71) Applicant: DSM IP Assets B.V. 6411 TE Heerlen (NL)

(72) Inventors: COX, Anthony NL-3062 DA Rotterdam (NL) KREBBER, Anke Palo Alto, California 94303 (US) BOVENBERG, Roelof, Ary, Lans Mountain View, California 95124 (US) CHEN, Yong Hong San Jose, California 95124 (US) JENNE, Stephane J. San Carlos, California 94070 (US) TOBIN, Matthew Foster City, California 94404 (US) TO LA CHING, Charlene Foster City, California 94404 (US) (74) Representative: Misset, Onno et al DSM Intellectual Property (Delft Office) P.O. Box 1 (600-0240) 2600 MA Delft 2600 MA Delft (NL)