(19)

(11)

EP 1 853 215 A2

(12)

(43) Date of publication: 14.11.2007 Bulletin 2007/46 (21) Application number: 06717692.5 (22) Date of filing: 06.01.2006

(51) International Patent Classification (IPC):  A61K 6/00(2006.01) (86) International application number: PCT/US2006/000524 (87) International publication number: WO 2006/074404 (13.07.2006 Gazette 2006/28)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK YU (30) Priority: 06.01.2005 US 593330 P 05.01.2006 US 306648 (71) Applicant: National Research Laboratories, Ltd. Cincinnati, OH 45247 (US)	(72) Inventors: GERALD L. Maurer Cincinnati, OH 45247 (US) GENDERS, J., David Elma, NY 14059 (US) (74) Representative: Catesby, Olivia Joanne et al Tomkins & Co 5 Dartmouth Road Dublin 6 Dublin 6 (IE)