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(11)

EP 1 853 269 A2

(12)

(88) Date of publication A3: 22.03.2007 (43) Date of publication: 14.11.2007 Bulletin 2007/46 (21) Application number: 06736043.8 (22) Date of filing: 24.02.2006

(51) International Patent Classification (IPC):  A61K 31/538(2006.01) C07D 405/14(2006.01) A61K 31/4709(2006.01) C07D 413/02(2006.01) (86) International application number: PCT/US2006/006615 (87) International publication number: WO 2006/093832 (08.09.2006 Gazette 2006/36)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK YU (30) Priority: 28.02.2005 US 656984 P 23.08.2005 US 710445 P 23.02.2006 US 776106 P (71) Applicant: Renovis, Inc. South San Francisco, CA 94080 (US)

(72) Inventors: KELLY, Michael Thousand Oaks, California 93060 (US) KINCAID, John San Mateo, California 94404 (US) DUNCTON, Matthew San Francisco, California 94107 (US) SAHASRABUDHE, Kiran San Mateo, California 94403 (US) JANAGANI, Satyanarayana Santa Clara, California 95050 (US) UPASANI, Ravindra, B. San Jose, California 95148 (US) WU, Guoxian Palto Alto, California 94306 (US) FANG, Yunfeng San Diego, California 92128 (US) WEI, Zhi-liang San Mateo, California 94403 (US) KAUB, Carl San Mateo, CA 94402 (US) (74) Representative: Jones Day  Rechtsanwälte, Attorneys-at-Law, Patentanwälte Prinzregentenstrasse 11 80538 München 80538 München (DE)