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(11)

EP 1 853 302 A2

(12)

(88) Date of publication A3: 02.11.2006 (43) Date of publication: 14.11.2007 Bulletin 2007/46 (21) Application number: 06735400.1 (22) Date of filing: 17.02.2006

(51) International Patent Classification (IPC):  A61K 38/20(2006.01) A61K 31/517(2006.01) A61K 31/4412(2006.01) A61K 31/502(2006.01) A61K 31/404(2006.01) A61P 35/00(2006.01) (86) International application number: PCT/US2006/005720 (87) International publication number: WO 2006/089150 (24.08.2006 Gazette 2006/34)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 18.02.2005 US 654341 P (71) Applicant: Novartis Vaccines and Diagnostics, Inc. Emeryville, CA 94662-8097 (US)

(72) Inventors: AUKERMAN, Sharon Lea, Chiron Corporation Emeryville, CA 94608 (US) DENIS-MIZE, Kimberly, Chiron Corporation Emeryville, CA 94608 (US) ELIAS, Laurence, Chiron Corporation Emeryville, CA 94608 (US) JALLAL, Bahija, Chiron Corporation Emeryville, CA 94608 (US) MENEZES, Daniel, Chiron Corporation Emeryville, CA 94608 (US) WITHERELL, Gary W., Chiron Corporation Emeryville, CA 94608 (US) (74) Representative: Marshall, Cameron John et al Carpmaels & Ransford 43-45 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)