(19)

(11)

EP 1 856 028 A1

(12)

(43) Date of publication: 21.11.2007 Bulletin 2007/47 (21) Application number: 06719111.4 (22) Date of filing: 20.01.2006

(51) International Patent Classification (IPC):  C07C 227/32(2006.01) (86) International application number: PCT/US2006/002147 (87) International publication number: WO 2006/081151 (03.08.2006 Gazette 2006/31)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 24.01.2005 US 646697 P (71) Applicant: Merck & Co., Inc. Rahway, NJ 07065-0907 (US)

(72) Inventors: XIAO, Yi Rahway, Nj 07065-0907 (US) ARMSTRONG, Joseph, D., III Rahway, NJ 07065-0907 (US) KRSKA, Shane, W. Rahway, NJ 07065-0907 (US) NJOLITO, Eugenia Rahway, NJ 07065 (US) RIVERA, Nelo, R. Rahway, NJ 07065-0907 (US) SUN, Yongkui Rahway, NJ 07065-0907 (US) ROSNER, Thorsten Rahway, NJ 07065-0907 (US) CLAUSEN, Andrew, M. Rahway, NJ 07065-0907 (US) (74) Representative: Buchan, Gavin MacNicol  Merck Sharp & Dohme Limited Hertford Road Hoddesdon, Herts. EN11 9BU Hoddesdon, Herts. EN11 9BU (GB)