(19)

(11)

EP 1 858 505 A2

(12)

(88) Date of publication A3: 30.11.2006 (43) Date of publication: 28.11.2007 Bulletin 2007/48 (21) Application number: 05825898.9 (22) Date of filing: 22.12.2005

(51) International Patent Classification (IPC):  A61K 31/22(2006.01) A61P 25/22(2006.01) A61K 36/25(2006.01) (86) International application number: PCT/IB2005/003903 (87) International publication number: WO 2006/067607 (29.06.2006 Gazette 2006/26)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 23.12.2004 GB 0428164 (71) Applicants: University of Basel 4003 Basel (CH) University of Bern 3012 Bern (CH) Swiss Tropical Institute 4002 Basel (CH)	(72) Inventors: SIMMEN, Urs CH-4052 Basel (CH) SIGEL, Erwin CH-3047 Bremgarten (CH) BRUN, Reto CH-4106 Therwil (CH) SEQUIN, Urs CH-4106 Therwil (CH) SENN, Martin 4102 Binningen (CH)