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(11)

EP 1 858 546 A2

(12)

(88) Date of publication A3: 07.12.2006 (43) Date of publication: 28.11.2007 Bulletin 2007/48 (21) Application number: 06736868.8 (22) Date of filing: 06.03.2006

(51) International Patent Classification (IPC):  A61K 38/26(2006.01) C12N 15/16(2006.01) C12N 15/18(2006.01) C07K 5/00(2006.01) A61K 38/40(2006.01) C12N 15/17(2006.01) C07K 14/76(2006.01) (86) International application number: PCT/US2006/007617 (87) International publication number: WO 2006/096515 (14.09.2006 Gazette 2006/37)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 04.03.2005 US 658140 P 22.03.2005 US 663757 P (71) Applicant: Biorexis Pharmaceutical Corporation King of Prussia, PA 19406-2675 (US)	(72) Inventors: SADEGHI, Homayoun King of Prussia, Pennsylvania 19406 (US) TURNER, Andrew J. King of Prussia, 19406 (US) PRIOR, Christopher P. King of Prussia, Pennsylvania 19406 (US) BALLANCE, David J. King Of Prussia, Pennsylvania 19406 (US) (74) Representative: Ford, Timothy James  Pfizer Limited European Patent Department Ramsgate Road Sandwich, Kent CT13 9NJ Sandwich, Kent CT13 9NJ (GB)