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(11)

EP 1 858 547 A1

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(43) Date of publication: 28.11.2007 Bulletin 2007/48 (21) Application number: 05782989.7 (22) Date of filing: 05.09.2005

(51) International Patent Classification (IPC):  A61K 39/00(2006.01) A61K 39/04(2006.01) A61K 48/00(2006.01) (86) International application number: PCT/BR2005/000179 (87) International publication number: WO 2006/024122 (09.03.2006 Gazette 2006/10)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 03.09.2004 BR PI0404983 (71) Applicant: Nanocore Biotecnologia Ltda CEP-14040-900 Ribeirao Preto, SP (BR)	(72) Inventors: RODRIGUES, José, Maciel, Jr. CEP-14090 São Paulo, SP (BR) LIMA, Karla de Melo CEP-14090-470 São Paulo, SP (BR) (74) Representative: Ramos Lucas, Maria Manuel  MarquesMarcas, Lda. Largo de São Domingos, 1 2910-092 Setúbal 2910-092 Setúbal (PT)