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(11)

EP 1 858 875 A2

(12)

(88) Date of publication A3: 26.10.2006 (43) Date of publication: 28.11.2007 Bulletin 2007/48 (21) Application number: 06708351.9 (22) Date of filing: 17.02.2006

(51) International Patent Classification (IPC):  C07D 339/04(2006.01) A61K 31/385(2006.01) (86) International application number: PCT/EP2006/060060 (87) International publication number: WO 2006/089861 (31.08.2006 Gazette 2006/35)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: HR (30) Priority: 24.02.2005 US 655428 P 24.02.2005 EP 05101405 (71) Applicant: Solvay Pharmaceuticals B.V. 1381 CP Weesp (NL)

(72) Inventors: DRUKARCH, Benjamin 1081 BT Amsterdam (NL) SCHOFFELMEER, Anton, N., M. 1081 BT Amsterdam (NL) VEENSTRA, Roelof, W. NL-1381 CP Weesp (NL) CHRISTEN, Marie-Odile NL-1381 CP Weesp (NL) BURGOT, Jean-Louise NL-1381 CP Weesp (NL) CHOLLET, Marylene NL-1381 CP Weesp (NL) IWEMA BAKKER, Wouter, I. NL-1381 CP Weesp (NL) VAN VLIET, Bernard, J. NL-1381 CP Weesp (NL) TULP, Martinus, Th. M. NL-1381 CP Weesp (NL) (74) Representative: Verhage, Marinus et al Octrooibureau Zoan B.V. P.O. Box 140 1380 AC Weesp 1380 AC Weesp (NL)