(19)

(11)

EP 1 859 042 A2

(12)

(88) Date of publication A3: 15.03.2007 (43) Date of publication: 28.11.2007 Bulletin 2007/48 (21) Application number: 06748385.9 (22) Date of filing: 14.03.2006

(51) International Patent Classification (IPC):  C12N 15/20(2006.01) (86) International application number: PCT/US2006/009229 (87) International publication number: WO 2006/099451 (21.09.2006 Gazette 2006/38)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 14.03.2005 US 661686 P 22.03.2005 US 664443 P (71) Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY New Brunswick, New Jersey 08901 (US)	(72) Inventors: PESTKA, Sidney North Caldwell, New Jersey 07006 (US) KRAUSE, Christopher, D. Nottingham, Pennsylvania 19362-0267 (US) (74) Representative: Chapman, Paul Gilmour et al Marks & Clerk 19 Royal Exchange Square Glasgow G1 3AE Glasgow G1 3AE (GB)