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EP 1 861 372 A1

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(43) Date of publication: 05.12.2007 Bulletin 2007/49 (21) Application number: 06735798.8 (22) Date of filing: 23.02.2006

(51) International Patent Classification (IPC):  C07D 215/50(2006.01) C07D 413/06(2006.01) C07D 409/06(2006.01) C07D 471/04(2006.01) A61K 31/47(2006.01) A61K 31/4375(2006.01) A61P 19/00(2006.01) C07D 401/06(2006.01) C07D 401/12(2006.01) C07D 413/12(2006.01) C07D 495/04(2006.01) A61K 31/506(2006.01) A61K 31/4365(2006.01) A61P 11/00(2006.01) (86) International application number: PCT/US2006/006287 (87) International publication number: WO 2006/091674 (31.08.2006 Gazette 2006/35)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK YU (30) Priority: 24.02.2005 US 655927 P (71) Applicant: MILLENNIUM PHARMACEUTICALS, INC. Cambridge, MA 02139 (US)

(72) Inventors: LITTLE, Jeremy, D. Wakefield, Massachusetts 01880 (US) GHOSH, Shomir Brookline, Massachusetts 02446 (US) HARRISON, Sean Belmont, Massachusetts 02478 (US) ELDER, Amy, E. Arlington, Massachusetts 02474 (US) RENOU, Christelle, C. Somerville, Massachusetts 02144 (US) CARSON, Kenneth, G. Princeton, New Jersey 08540 (US) (74) Representative: Harris, Jennifer Lucy et al Kilburn & Strode 20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)