(19)

(11)

EP 1 861 406 A2

(12)

(88) Date of publication A3: 22.02.2007 (43) Date of publication: 05.12.2007 Bulletin 2007/49 (21) Application number: 06738095.6 (22) Date of filing: 08.03.2006

(51) International Patent Classification (IPC):  C07D 489/00(2006.01) A61P 25/04(2006.01) A61K 31/485(2006.01) (86) International application number: PCT/US2006/008990 (87) International publication number: WO 2006/099351 (21.09.2006 Gazette 2006/38)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 11.03.2005 US 660645 P (71) Applicant: NORAMCO, INC. Athens GA 30601-8001 (US)	(72) Inventors: HAGEN, Eric, J. Lafayette, Indiana 47905 (US) PARK, Aeri West Lafayette, Indiana 07906 (US) (74) Representative: Fisher, Adrian John et al CARPMAELS & RANSFORD 43-45 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)