(19)

(11)

EP 1 861 714 A2

(12)

(88) Date of publication A3: 12.04.2007 (43) Date of publication: 05.12.2007 Bulletin 2007/49 (21) Application number: 06736296.2 (22) Date of filing: 24.02.2006

(51) International Patent Classification (IPC):  G01N 33/574(2006.01) (86) International application number: PCT/US2006/006948 (87) International publication number: WO 2006/091949 (31.08.2006 Gazette 2006/35)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 24.02.2005 US 655786 P (71) Applicant: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. Atlanta, GA 30303 (US)	(72) Inventor: LIU, Zhi-Ren Atlanta, Georgia 30345-1923 (US) (74) Representative: Larcher, Dominique  Cabinet Vidon, 16 B, rue Jouanet, B.P. 90333 35703 Rennes Cédex 7 35703 Rennes Cédex 7 (FR)