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EP 1 863 342 A1

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(43) Date of publication: 12.12.2007 Bulletin 2007/50 (21) Application number: 05810134.6 (22) Date of filing: 17.02.2005

(51) International Patent Classification (IPC):  A01N 1/00(2006.01) A61K 35/18(2006.01) A01N 1/02(2006.01) (86) International application number: PCT/US2005/005004 (87) International publication number: WO 2006/088455 (24.08.2006 Gazette 2006/34)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR LV MK YU (71) Applicant: UNIVERSITY OF CINCINNATI Cincinnati, OH 45267-0829 (US)	(72) Inventors: HESS, John, R. Bethesda, MD 20817 (US) GREENWALT, Tibor, G. Cincinnati, OH 45208 (US) (74) Representative: Pfenning, Meinig & Partner GbR  Patent- und Rechtsanwälte Theresienhöhe 13 80339 München 80339 München (DE)