(19)

(11)

EP 1 863 914 A1

(12)

(43) Date of publication: 12.12.2007 Bulletin 2007/50 (21) Application number: 06721759.6 (22) Date of filing: 03.04.2006

(51) International Patent Classification (IPC):  C12N 15/31(2006.01) C12Q 1/68(2006.01) C12P 19/34(2006.01) A61K 39/04(2006.01) C12N 1/21(2006.01) C40B 40/06(2006.01) C12P 21/02(2006.01) C07H 21/00(2006.01) C12N 15/74(2006.01) C07K 14/35(2006.01) (86) International application number: PCT/CA2006/000503 (87) International publication number: WO 2006/102767 (05.10.2006 Gazette 2006/40)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 01.04.2005 US 667243 P (71) Applicant: McGill University Montreal, QC H3A 2T5 (CA)	(72) Inventors: BEHR, Marcel Westmount, Québec H3V 3A7 (CA) MOSTOWY, Serge Westmount, Québec H3Z 1N6 (CA) CHARLET, Danielle Montréal, Québec H2W 2G5 (CA) ALEXANDER, David Montréal, Québec H4A 3B4 (CA) (74) Representative: Garnett, David et al Harrison Goddard Foote Orlando House 11c Compstall Road Marple Bridge GB-Stockport SK6 5HH GB-Stockport SK6 5HH (GB)