(19)

(11)

EP 1 863 939 A2

(12)

(88) Date of publication A3: 10.05.2007 (43) Date of publication: 12.12.2007 Bulletin 2007/50 (21) Application number: 06748451.9 (22) Date of filing: 20.03.2006

(51) International Patent Classification (IPC):  C12Q 1/68(2006.01) A61K 9/20(2006.01) (86) International application number: PCT/US2006/009913 (87) International publication number: WO 2006/102177 (28.09.2006 Gazette 2006/39)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK YU (30) Priority: 22.03.2005 US 664248 P 05.12.2005 US 742401 P (71) Applicants: Novartis AG 4056 Basel (CH) NOVARTIS-PHARMA GMBH 1230 Vienna (AT) AT	(72) Inventors: GU, Jessie Framingham, MA 01702 (US) MEYER, Joanne Framingham, MA 01702 (US) (74) Representative: Crawley, Patrick Edward et al Novartis AG Corporate Intellectual Property 4002 Basel 4002 Basel (CH)