(19)

(11)

EP 1 865 942 A2

(12)

(88) Date of publication A3: 07.09.2007 (43) Date of publication: 19.12.2007 Bulletin 2007/51 (21) Application number: 06708757.7 (22) Date of filing: 14.03.2006

(51) International Patent Classification (IPC):  A61K 31/166(2006.01) C07D 493/04(2006.01) A61P 33/06(2006.01) A61K 31/122(2006.01) C07C 50/36(2006.01) (86) International application number: PCT/EP2006/060707 (87) International publication number: WO 2006/097472 (21.09.2006 Gazette 2006/38)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK YU (30) Priority: 14.03.2005 US 661596 P (71) Applicants: Universität Giessen 35390 Giessen (DE) Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. 80539 München (DE)	(72) Inventors: BECKER-BRANDENBURG, Katja 35582 Wetzlar-Dudenhofen (DE) ZIMMERMANN, Herbert 69198 Schriesheim (DE) FRITZ-WOLF, Karin 69181 Leimen (DE) (74) Representative: Eder, Michael  df-mp Fünf Höfe Theatinerstrasse 16 80333 München 80333 München (DE)