(19)

(11)

EP 1 868 602 A1

(12)

(43) Date of publication: 26.12.2007 Bulletin 2007/52 (21) Application number: 06740950.8 (22) Date of filing: 14.04.2006

(51) International Patent Classification (IPC):  A61K 31/4178(2006.01) A61P 25/00(2006.01) A61K 31/135(2006.01) A61P 11/00(2006.01) (86) International application number: PCT/US2006/014099 (87) International publication number: WO 2006/113448 (26.10.2006 Gazette 2006/43)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 15.04.2005 US 672168 P (71) Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS Urbana, IL 61801 (US)	(72) Inventors: RADULOVACKI, Miodrag Chicago, Illinois 60607-3203 (US) CARLEY, David, W. Evanston, Illinois 60201-2237 (US) (74) Representative: Sutcliffe, Nicholas Robert  Mewburn Ellis LLP York House, 23 Kingsway London WC2B 6HP London WC2B 6HP (GB)