(19)

(11)

EP 1 869 069 A2

(12)

(88) Date of publication A3: 26.10.2006 (43) Date of publication: 26.12.2007 Bulletin 2007/52 (21) Application number: 06716638.9 (22) Date of filing: 03.03.2006

(51) International Patent Classification (IPC):  C07K 7/66(2006.01) A61K 38/04(2006.01) (86) International application number: PCT/NL2006/000111 (87) International publication number: WO 2006/093405 (08.09.2006 Gazette 2006/36)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 04.03.2005 EP 05075540 (71) Applicant: Stichting voor de Technische Wetenschappen 3527 JP Utrecht (NL)	(72) Inventors: AYRES, Lee NL-6521 DA Nijmegen (NL) GROTENBREG, Gijsbert, Marnix Sommerville, MA 02143 (US) OVERHAND, Mark NL-2312 SZ Leiden (NL) VAN HEST, Jan, Cornelis, Maria NL-6522 DL Nijmegen (NL) (74) Representative: Hatzmann, Martin  VEREENIGDE Johan de Wittlaan 7 2517 JR Den Haag 2517 JR Den Haag (NL)