(19)

(11)

EP 1 869 214 A2

(12)

(88) Date of publication A3: 28.06.2007 (43) Date of publication: 26.12.2007 Bulletin 2007/52 (21) Application number: 06739311.6 (22) Date of filing: 22.03.2006

(51) International Patent Classification (IPC):  C12Q 1/68(2006.01) (86) International application number: PCT/US2006/010464 (87) International publication number: WO 2006/104812 (05.10.2006 Gazette 2006/40)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK YU (30) Priority: 25.03.2005 US 665168 P (71) Applicants: Novartis AG 4056 Basel (CH) NOVARTIS-PHARMA GMBH 1230 Vienna (AT) AT	(72) Inventors: CHEN, Hong Newton, MA 02459 (US) HUGHES, Thomas, Edward Concord, MA 01742 (US) (74) Representative: Crawley, Patrick Edward  Novartis AG Corporate Intellectual Property 4002 Basel 4002 Basel (CH)