(19)

(11)

EP 1 871 337 A1

(12)

(43) Date of publication: 02.01.2008 Bulletin 2008/01 (21) Application number: 05802954.7 (22) Date of filing: 04.10.2005

(51) International Patent Classification (IPC):  A61K 8/20(2006.01) A61K 8/30(2006.01) A61K 9/70(2006.01) A61K 8/22(2006.01) A61K 8/38(2006.01) A61F 13/00(2006.01) (86) International application number: PCT/US2005/035518 (87) International publication number: WO 2006/107334 (12.10.2006 Gazette 2006/41)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: HR (30) Priority: 31.03.2005 WO PCT/US2005/010941 (71) Applicant: SMITHKLINE BEECHAM CORPORATION Philadelphia, PA 19101 (US)	(72) Inventor: VELADA, Jose Reybridge Surrey (GB) (74) Representative: Reeves, Julie Frances  GlaxoSmithKline Corporate Intellectual Property (CN9.25.1) 980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)