(19)
(11) EP 1 871 341 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
11.04.2012 Bulletin 2012/15

(45) Mention of the grant of the patent:
29.02.2012 Bulletin 2012/09

(21) Application number: 06727346.6

(22) Date of filing: 23.03.2006
(51) International Patent Classification (IPC): 
A61K 9/127(2006.01)
(86) International application number:
PCT/IB2006/000635
(87) International publication number:
WO 2006/100567 (28.09.2006 Gazette 2006/39)

(54)

CHARGED LIPOPROTEIN COMPLEXES AND THEIR USES

GELADENE LIPOPROTEIN-KOMPLEXE UND IHRE VERWENDUNGEN

COMPLEXES DE LIPOPROTÉINES CHARGÉS ET UTILISATION DE CES COMPLEXES


(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

(30) Priority: 24.03.2005 US 665180 P

(43) Date of publication of application:
02.01.2008 Bulletin 2008/01

(60) Divisional application:
10010652.5 / 2327396
10010660.8 / 2289490

(73) Proprietor: Cerenis Therapeutics Holding SA
31670 Labege (FR)

(72) Inventor:
  • DASSEUX, Jean-Louis H.
    F-31320 Vieille-Toulouse (FR)

(74) Representative: Woolley, Lindsey Claire et al
Mewburn Ellis LLP 33 Gutter Lane
London EC2V 8AS
London EC2V 8AS (GB)


(56) References cited: : 
WO-A-03/029294
WO-A-03/096983
   
  • DAVIDSON W S ET AL: "The molecular basis for the difference in charge between pre-beta- and alpha-migrating high density lipoproteins." THE JOURNAL OF BIOLOGICAL CHEMISTRY. 25 MAR 1994, vol. 269, no. 12, 25 March 1994 (1994-03-25), pages 8959-8965, XP002391326 ISSN: 0021-9258
  • STAMLER C J ET AL: "PHOSPHATIDYLINOSITOL PROMOTES CHOLESTEROL TRANSPORT IN VIVO" JOURNAL OF LIPID RESEARCH, BETHESDA, MD, US, vol. 41, no. 8, 2000, pages 1214-1221, XP001077804 ISSN: 0022-2275
  • PAPAPANAGIOTOU A ET AL: "Effects of hormone replacement therapy on the phospholipid composition of high density lipoproteins in postmenopausal women." JOURNAL OF OBSTETRICS AND GYNAECOLOGY : THE JOURNAL OF THE INSTITUTE OF OBSTETRICS AND GYNAECOLOGY. JAN 2001, vol. 21, no. 1, January 2001 (2001-01), pages 56-61, XP009069758 ISSN: 0144-3615
  • NYHOLM T ET AL: "Properties of palmitoyl phosphatidylcholine, sphingomyelin, and dihydrosphingomyelin bilayer membranes as reported by different fluorescent reporter molecules" BIOPHYSICAL JOURNAL, NEW YORK, US, US, vol. 84, no. 2, February 2003 (2003-02), pages 987-997, XP002352947 ISSN: 0006-3495
  • FORTE TRUDY M ET AL: "Recruitment of cell phospholipids and cholesterol by apolipoproteins A-II and A-I: Formation of nascent apolipoprotein-specific HDL that differ in size, phospholipid composition, and reactivity with LCAT", JOURNAL OF LIPID RESEARCH, vol. 36, no. 1, 1995, pages 148-157, ISSN: 0022-2275
  • BOJANOVSKI D ET AL: "HUMAN APOLIPOPROTEIN A-I ISOPROTEIN METABOLISM: PROAPOA-I CONVERSION TO MATURE APOA-I", JOURNAL OF LIPID RESEARCH, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, INC, US, vol. 26, no. 2, 1 January 1985 (1985-01-01), pages 185-193, XP001205601, ISSN: 0022-2275
  • BOLIN DELMAS J ET AL: "Binding of lecithin:cholesterol acyltransferase to reconstituted high density lipoproteins is affected by their lipid but not apolipoprotein composition", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 269, no. 10, 1994, pages 7429-7434, ISSN: 0021-9258
  • BOLIN D J ET AL: "Sphingomyelin Inhibits the Lecithin-Cholesterol Acyltransferase Reaction with Reconstituted High Density Lipoproteins by Decreasing Enzyme Binding", JOURNAL OF BIOLOGICAL CHEMISTRY, THE AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, INC., BALTIMORE, MD, US, vol. 271, no. 32, 9 August 1996 (1996-08-09), pages 19152-19158, XP002613348, ISSN: 0021-9258, DOI: DOI:10.1074/JBC.271.32.19152
 
Remarks:
The file contains technical information submitted after the application was filed and not included in this specification
 
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).