(19)
(11) EP 1 871 377 A1

(12)

(43) Date of publication:
02.01.2008 Bulletin 2008/01

(21) Application number: 06709898.8

(22) Date of filing: 24.02.2006
(51) International Patent Classification (IPC): 
A61K 31/519(2006.01)
 C07D 471/04(2006.01)
(86) International application number:
PCT/GB2006/000671
(87) International publication number:
WO 2006/090169 (31.08.2006 Gazette 2006/35)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

(30) Priority: 25.02.2005 GB 0503961
25.02.2005 US 656178 P
05.12.2005 US 742403 P

(71) Applicant: Kudos Pharmaceuticals Ltd
15 Stanhope Gate London W1K ILN (GB)

(72) Inventors:
  • HUMMERSONE, Marc Geoffrey Kudos Pharma. Ltd.
    Cambridge, Cambridgeshire CB4 0WG (GB)
  • GOMEZ, Sylvie Kudos Pharma. Ltd.
    Cambridge Cambridgeshire CB4 0WG (GB)
  • MENEAR, Keith Allan Kudos Pharma. Ltd.
    Cambridge Cambridgeshire CB4 0WG (GB)
  • COCKCROFT, Xiao-ling Fan Kudos Pharma. Ltd.
    Cambridge Cambridgeshire CB4 0WG (GB)
  • EDWARDS, Peter Kudos Pharma. Ltd.
    Cambridge Cambridgeshire CB4 0WG (GB)
  • LOH, Vincent Junior Ming Lai Kudos Pharma. Ltd.
    Cambridge Cambridgeshire CB4 0WG (GB)
  • SMITH, Graeme Cameron Murray Kudos Pharma. Ltd.
    Cambridge Cambridgeshire CB4 0WG (GB)

(74) Representative: Berry, Ian Gordon et al
AstraZeneca AB Global Intellectual Property
151 85 Södertälje
151 85 Södertälje (SE)

   


(54) 2,4-DIAMINO-PYRIDOPYRIMIDINE DERIVATIVES AND THEIR USE AS MTOR INHIBITORS