(19)

(11)

EP 1 871 412 A2

(12)

(88) Date of publication A3: 22.02.2007 (43) Date of publication: 02.01.2008 Bulletin 2008/01 (21) Application number: 06726623.9 (22) Date of filing: 03.04.2006

(51) International Patent Classification (IPC):  A61K 39/245(2006.01) C12N 15/62(2006.01) A61P 37/02(2006.01) C07K 14/03(2006.01) C07K 19/00(2006.01) C12N 15/63(2006.01) A61P 37/06(2006.01) (86) International application number: PCT/GB2006/001219 (87) International publication number: WO 2006/103472 (05.10.2006 Gazette 2006/40)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 01.04.2005 GB 0506721 (71) Applicant: THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW Glasgow, G12 8QQ (GB)	(72) Inventors: BLACKBOURN, David J. Cancer Res. UK Inst. for Cancer Studies Edgbaston, Birmingham B15 2TT (GB) RAZAEE, Seyyed A. Cancer Res. UK Inst. for Cancer Studies Edgbaston, Birmingham B15 2TT (GB) (74) Representative: Forrest, Graham Robert et al Mewburn Ellis LLP York House 23 Kingsway London WC2B 6HP London WC2B 6HP (GB)