(19)

(11)

EP 1 871 741 A2

(12)

(88) Date of publication A3: 26.04.2007 (43) Date of publication: 02.01.2008 Bulletin 2008/01 (21) Application number: 06749333.8 (22) Date of filing: 04.04.2006

(51) International Patent Classification (IPC):  C07D 205/08(2006.01) A61K 31/397(2006.01) A61P 7/02(2006.01) C07D 227/087(2006.01) A61P 11/02(2006.01) (86) International application number: PCT/US2006/012665 (87) International publication number: WO 2006/108039 (12.10.2006 Gazette 2006/41)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 04.04.2005 US 668325 P (71) Applicant: Daiamed, Inc. Cambridge, MA 02141 (US)

(72) Inventors: BANNISTER, Thomas Palm Beach Gardens, Florida 33418 (US) CELATKA, Cassandra Hull, Massachusetts 02045 (US) CHANDRAKUMAR, Nizal, S North Grafton, Massachusetts 01536 (US) DENG, Hongfeng Acton, Massachusetts 01720 (US) GUO, Zihong Southbury, Connecticut 06488 (US) JIN, Lei Wellesley, Massachusetts 02481 (US) LAZAROVA, Tsvetelina Brookline, Massachusetts 02445 (US) LIN, Jian Walpole, Massachusetts 02081 (US) MOE, Scott, T. Marlborough, Massachusetts 01752 (US) NAGAFUJI, Pamela Cambridge, Massachusetts 02139 (US) NAVIA, Manuel Lexington, Massachusetts 02420 (US) RIPKA, Amy Winthrop, Massachusetts 02152 (US) RYNKIEWICZ, Michael, J Boston, Massachusetts 02114 (US) SPEAR, Kerry, L Concord, Massachusetts 01742 (US) STRICKLER, James, E Milton, Massachusetts 02186 (US) XIE, Roger Southborough, Massachusetts 01772 (US) (74) Representative: Harrison Goddard Foote  Belgrave Hall Belgrave Street Leeds LS2 8SS Leeds LS2 8SS (GB)