(19)

(11)

EP 1 871 787 A2

(12)

(88) Date of publication A3: 14.12.2006 (43) Date of publication: 02.01.2008 Bulletin 2008/01 (21) Application number: 06724173.7 (22) Date of filing: 10.04.2006

(51) International Patent Classification (IPC):  C07K 7/08(2006.01) A61K 38/16(2006.01) A61K 38/10(2006.01) C07K 14/195(2006.01) (86) International application number: PCT/EP2006/003237 (87) International publication number: WO 2006/108586 (19.10.2006 Gazette 2006/42)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 11.04.2005 EP 05300270 26.04.2005 EP 05300319 (71) Applicants: Sanofi Pasteur 69367 Lyon Cedex 07 (FR) BIOSYNTH 53040 Repolano Terme (IT)

(72) Inventors: PORRO, Massimo I-53040 Rapolano Terme-Siena (IT) KRELL, Tino E-18198 Huetor Vega (ES) MISTRETTA, Noëlle F-69210 Saint Bel (FR) MOREAU, Monique F-69007 Lyon (FR) RUSTICI, Alessandro I-53018 Sovicille (IT) VELUCCHI, Massimo I-52044 Cortona (IT) (74) Representative: Ayroles, Marie-Pauline et al Sanofi Pasteur Propriété Intellectuelle 2, avenue pont Pasteur 69367 Lyon Cedex 07 69367 Lyon Cedex 07 (FR)