CHIMERIC PROTEINS COMPRISING YERSINIA YOP, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

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EP 1 871 880 B8

(12)	CORRECTED EUROPEAN PATENT SPECIFICATION
	Note: Bibliography reflects the latest situation

(15)	Correction information:
	Corrected version no 1 (W1 B1)

(48)	Corrigendum issued on:
	12.09.2012 Bulletin 2012/37

(45)	Mention of the grant of the patent:
	08.08.2012 Bulletin 2012/32

(21)	Application number: 06728257.4

(22)	Date of filing: 10.04.2006

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International Patent Classification (IPC):

C12N 15/00^(2006.01)
A61K 38/00^(2006.01)

C07K 19/00^(2006.01)

(86)	International application number:
	PCT/IL2006/000456

(87)	International publication number:
	WO 2006/109303 (19.10.2006 Gazette 2006/42)

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CHIMERIC PROTEINS COMPRISING YERSINIA YOP, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

YERSINIA YOP UMFASSENDE CHIMÄRE PROTEINE, DEREN HERSTELLUNG UND DIESE ENTHALTENDE PHARMAZEUTISCHE ZUSAMMENSETZUNGEN

PROTEINES CHIMERES COMPRENANT YERSINIA YOP, LEUR PREPARATION, ET COMPOSITIONS PHARMACEUTIQUES CONTENANT LESDITES PROTEINES

(84)	Designated Contracting States:
	AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
	Designated Extension States:
	AL BA HR MK YU

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Priority:

11.04.2005 IL 16795905

(43)	Date of publication of application:
	02.01.2008 Bulletin 2008/01

(73)	Proprietor: YEDA RESEARCH AND DEVELOPMENT CO., LTD.
	76100 Rehovot (IL)

(72)	Inventors:
	WALLACH, David 76406 Rehovot (IL) APPEL, Elena 75491 Rishon Le Zion (IL)

(74)	Representative: Vossius & Partner
	Siebertstrasse 4 81675 München 81675 München (DE)

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References cited: :

WO-A-98/56817
WO-A-02/096467

WO-A-99/52563

BOYD A P ET AL: "Yersinia enterocolitica can deliver Yop proteins into a wide range of cell types: Development of a delivery system for heterologous proteins" EUROPEAN JOURNAL OF CELL BIOLOGY, WISSENSCHAFLICHE VERLAGSGESELLSCHAFT, STUTTGART,, DE, vol. 79, no. 10, October 2000 (2000-10), pages 659-671, XP004954429 ISSN: 0171-9335
COOMBES B K ET AL: "Insertion of the bacterial type III translocon: not your average needle stick" TRENDS IN MICROBIOLOGY, ELSEVIER SCIENCE LTD., KIDLINGTON, GB, vol. 13, no. 3, March 2005 (2005-03), pages 92-95, XP004768867 ISSN: 0966-842X
CORNELIS GUY R: "Molecular and cell biology aspects of plague" PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 97, no. 16, 1 August 2000 (2000-08-01), pages 8778-8783, XP002399287 ISSN: 0027-8424
RUCKDESCHEL KLAUS ET AL: "Arginine-143 of Yersinia enterocolitica YopP crucially determines isotype-related NF-kappaB suppression and apoptosis induction in macrophages" INFECTION AND IMMUNITY, vol. 69, no. 12, December 2001 (2001-12), pages 7652-7662, XP002399288 ISSN: 0019-9567
RAHMAN MASMUDUR M ET AL: "Modulation of tumor necrosis factor by microbial pathogens" PLOS PATHOGENS, vol. 2, no. 2, February 2006 (2006-02), pages 66-77 URL, XP002399289 ISSN: 1553-7366(print) 1553-7374(ele

Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).