(19)

(11)

EP 1 871 886 A2

(12)

(88) Date of publication A3: 08.03.2007 (43) Date of publication: 02.01.2008 Bulletin 2008/01 (21) Application number: 06749773.5 (22) Date of filing: 05.04.2006

(51) International Patent Classification (IPC):  C12N 15/52(2006.01) C12N 5/10(2006.01) C12N 15/63(2006.01) C12N 9/48(2006.01) (86) International application number: PCT/US2006/013501 (87) International publication number: WO 2006/110760 (19.10.2006 Gazette 2006/42)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 08.04.2005 US 102501 (71) Applicant: GENENTECH, INC. South San Francisco California 94080 (US)

(72) Inventors: DOWD, Patrick San Francisco, California 94114 (US) FRANTZ, Gretchen San Francisco, California 94123 (US) POLAKIS, Paul Mill Valley, California 94941 (US) SMITH, Victoria Burlingame, California 94010 (US) SPENCER, Susan Tiburon, California 94920 (US) WU, Thomas San Francisco, California 94110 (US) ZHANG, Zemin Foster City, California 94404 (US) (74) Representative: Denison, Christopher Marcus  Mewburn Ellis LLP York House 23 Kingsway London WC2B 6HP London WC2B 6HP (GB)