(19)
(11) EP 1 871 906 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
21.11.2012 Bulletin 2012/47

(45) Mention of the grant of the patent:
10.10.2012 Bulletin 2012/41

(21) Application number: 06740852.6

(22) Date of filing: 07.04.2006
(51) International Patent Classification (IPC): 
C12Q 1/68(2006.01)
C07H 21/04(2006.01)
 C07H 21/02(2006.01)
(86) International application number:
PCT/US2006/013462
(87) International publication number:
WO 2006/110735 (19.10.2006 Gazette 2006/42)

(54)

GENOTYPING HLA LOCI

GENOTYPISIERUNG VON HLA-LOCI

GÉNOTYPAGE DE LOCI DE HLA

(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

(30) Priority: 08.04.2005 US 669760 P

(43) Date of publication of application:
02.01.2008 Bulletin 2008/01

(73) Proprietor: Linkage Biosciences, Inc.
South San Francisco, CA 94080 (US)

(72) Inventor:
  • ANTOVICH, Zachary
    San Francisco, California 94123 (US)

(74) Representative: Sexton, Jane Helen 
J A Kemp 14 South Square Gray's Inn
London WC1R 5JJ
London WC1R 5JJ (GB)


(56) References cited: : 
US-A1- 2003 165 884
 US-A1- 2004 002 073
   
  • DOWNING J ET AL: "Five-locus HLA typing of hematopoietic stem cell donor volunteers using PCR sequence specific primers" GENETIC TESTING, LARCHMONT, NY, US, vol. 8, no. 3, 1 October 2004 (2004-10-01), pages 301-312, XP009117560 ISSN: 1090-6576
  • TIEMANN C ET AL: "RAPID DNA TYPING OFHLA-B27 ALLELE BY REAL-TIME PCR USINGLIGHTCYCLER TECHNOLOGY" CLINICAL LABORATORY, CLIN LAB PUBLICATIONS, HEIDELBERG, vol. 47, no. 3-4, 1 January 2001 (2001-01-01), pages 131-134, XP008072918 ISSN: 1433-6510
  • SLATEVA K ET AL: "HLA-DRB FLUOROTYPING BASED ON SYBR GREEN MEDIATED MELTING CURVES" TISSUE ANTIGENS, MUNKSGAARD, COPENHAGEN, DK, vol. 59, no. 2, SUPPL, 18 May 2002 (2002-05-18), page 13, XP001181079 ISSN: 0001-2815
  • FUKUSHIMA ET AL.: 'Duplex Real Time SYBR Green PCR Assays for Detection of 17 Species of Food or Waterborne Pathogens in Stools' JOURNAL OF CLINICAL MICROBIOLOGY vol. 41, pages 5314 - 5346, XP002400106
  • MONIS P T ET AL: "Comparison of SYTO9 and SYBR Green I for real-time polymerase chain reaction and investigation of the effect of dye concentration on amplification and DNA melting curve analysis", ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS INC, NEW YORK, vol. 340, no. 1, 1 May 2005 (2005-05-01), pages 24-34, XP004816986, ISSN: 0003-2697, DOI: 10.1016/J.AB.2005.01.046
  • GIGLIO STEVEN ET AL: "Demonstration of preferential binding of SYBR Green I to specific DNA fragments in real-time multiplex PCR.", NUCLEIC ACIDS RESEARCH 15 NOV 2003 LNKD- PUBMED:14602929, vol. 31, no. 22, 15 November 2003 (2003-11-15), page e136, ISSN: 1362-4962
  • ANONYMOUS, [Online] Retrieved from the Internet: <URL:http://www.pcrstation.com/pcr-troubles hooting/> [retrieved on 2009-11-16]
  • KWOK S ET AL: "Effects of primer-template mismatches on the polymerase chain reaction: human immunodeficiency virus type 1 model studies", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 18, no. 4, 25 February 1990 (1990-02-25), pages 999-1005, XP002220845, ISSN: 0305-1048
  • BON MA ET AL: "GENOTYPING OF HLA-B27 BYREAL-TIME PCR WITHOUT HYBRIDIZATION PROBES", CLINICAL CHEMISTRY, AMERICAN ASSOCIATION FOR CLINICAL CHEMISTRY, WASHINGTON, DC, vol. 46, no. 7, 1 January 2000 (2000-01-01), pages 1000-1002, XP008072915, ISSN: 0009-9147
  • GAFFNEY DAIRENA ET AL: "A PCR based method to determine the Kalow allele of the cholinesterase gene: The E-1-k allele frequency and its significance in the normal population", JOURNAL OF MEDICAL GENETICS, BMJ PUBLISHING GROUP, LONDON, GB, [Online] vol. 31, no. 3, 1 March 1994 (1994-03-01), pages 248-250, XP009152985, ISSN: 0022-2593 Retrieved from the Internet: URL:http://www.ncbi.nlm.nih.gov/pmc/articl es/PMC1049753/pdf/jmedgene00282 0076.pdf>
  • BUNCE M ET AL: "Phototyping: comprehensive DNA typing for HLA-A, B, C, DRB1, DRB3, DRB4, DRB5 & DQB1 by PCR with 144 primer mixes utilizing sequence-specific primers (PCR-SSP)", TISSUE ANTIGENS, MUNKSGAARD, COPENHAGEN, DK, vol. 46, 1 January 1995 (1995-01-01), pages 355-367, XP008096257, ISSN: 0001-2815, DOI: 10.1111/J.1399-0039.1995.TB03127.X
  • C Tse ET AL: "Quantification des acides nucléiques par PCR quantitative en temps réel", Ann Biol Clin, 1 May 2003 (2003-05-01), pages 279-293, XP55009529, Retrieved from the Internet: URL:http://www.jle.com/e-docs/00/03/FE/CF/ vers_alt/VersionPDF.pdf [retrieved on 2011-10-14]
  • RIRIE K M ET AL: "PRODUCT DIFFERENTIATION BY ANALYSIS OF DNA MELTING CURVES DURING THE POLYMERASE CHAIN REACTION", ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS INC, NEW YORK, vol. 245, no. 2, 1 January 1997 (1997-01-01), pages 154-160, XP001015991, ISSN: 0003-2697, DOI: 10.1006/ABIO.1996.9916
 
Remarks:
The file contains technical information submitted after the application was filed and not included in this specification
 
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).