(19)

(11)

EP 1 874 734 A1

(12)

(43) Date of publication: 09.01.2008 Bulletin 2008/02 (21) Application number: 06708303.0 (22) Date of filing: 16.02.2006

(51) International Patent Classification (IPC):  C07D 233/90(2006.01) C07D 403/12(2006.01) C07D 401/06(2006.01) C07D 405/04(2006.01) C07D 405/12(2006.01) C07D 405/06(2006.01) C07D 401/12(2006.01) A61K 31/4164(2006.01) A61P 37/00(2006.01) A61P 29/00(2006.01) C07D 417/04(2006.01) (86) International application number: PCT/EP2006/060009 (87) International publication number: WO 2006/087355 (24.08.2006 Gazette 2006/34)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: HR (30) Priority: 16.02.2005 EP 05101171 16.02.2005 US 653091 P (71) Applicant: Solvay Pharmaceuticals B.V. 1381 CP Weesp (NL)	(72) Inventors: LANGE, Josephus, H. M. c/o IPSI Department NL-1381 CP Weesp (NL) STUIVENBERG, Herman H. c/o IPSI Department NL-1381 CP Weesp (NL) VAN VLIET, Bernard J. c/o IPSI Department NL-1381 CP Weesp (NL) (74) Representative: Verhage, Marinus et al Octrooibureau Zoan B.V., P.O. Box 140 1380 CP Weesp 1380 CP Weesp (NL)