(19)

(11)

EP 1 874 768 A2

(12)

(88) Date of publication A3: 30.08.2007 (43) Date of publication: 09.01.2008 Bulletin 2008/02 (21) Application number: 06758426.8 (22) Date of filing: 20.04.2006

(51) International Patent Classification (IPC):  C07D 471/02(2006.01) C07D 498/02(2006.01) C07D 515/02(2006.01) A61K 31/44(2006.01) C07D 491/02(2006.01) C07D 513/02(2006.01) A01N 43/42(2006.01) (86) International application number: PCT/US2006/014807 (87) International publication number: WO 2006/113837 (26.10.2006 Gazette 2006/43)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK YU (30) Priority: 20.04.2005 US 673120 P (71) Applicant: SMITHKLINE BEECHAM CORPORATION Philadelphia, PA 19101 (US)	(72) Inventors: SEEFELD, Mark, Andrew Collegeville, PA 19426 (US) ROUSE, Meagan, B. Collegeville, PA 19426 (US) HEERDING, Dirk, A. Collegeville, PA 19426 (US) (74) Representative: Sewell, Richard Charles et al GlaxoSmithKline Corporate Intellectual Property CN925.1 980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)