(19)
(11) EP 1 874 953 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
24.12.2008 Bulletin 2008/52

(45) Mention of the grant of the patent:
22.10.2008 Bulletin 2008/43

(21) Application number: 06750810.1

(22) Date of filing: 20.04.2006
(51) International Patent Classification (IPC): 
C12Q 1/48(2006.01)
(86) International application number:
PCT/US2006/014860
(87) International publication number:
WO 2006/113862 (26.10.2006 Gazette 2006/43)

(54)

METHODS FOR DETERMINING PHOSPHORYLTRANSFERASE ACTIVITY USING ADENOSINE 5'-TRIPHOSPHATE (ATP)-GAMMA-S

VERFAHREN ZUR BESTIMMUNG VON PHOSPHORYLTRANSFERASE-AKTIVITÄT UNTER VERWENDUNG VON ADENOSIN-5'-TRIPHOSPHAT (ATP)-GAMMA-S

PROCEDES DE DETERMINATION DE L'ACTIVITE D'UNE PHOSPHORYLTRANSFERASE AU MOYEN D'ADENOSINE 5'-TRIPHOSPHATE (ATP)-GAMMA-S

(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

(30) Priority: 20.04.2005 US 110435

(43) Date of publication of application:
09.01.2008 Bulletin 2008/02

(73) Proprietors:
  • BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    D-55216 Ingelheim (DE)
    Designated Contracting States:
    AT BE BG CH CY CZ DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR 
  • Boehringer Ingelheim Pharma GmbH & Co. KG
    55216 Ingelheim (DE)
    Designated Contracting States:
    DE 

(72) Inventors:
  • YINGLING, Jeffrey David Boehringer Ingelheim Pharm. Inc.
    Ridgefield, CT 06877-0368 (US)
  • JAKES, Scott, Boehringer Ingelheim Pharm. Inc.
    Ridgefield, CT 06877-0368 (US)
  • TERENZIO, Donna, Boehringer Ingelheim Pharm. Inc.
    Ridgefield, CT 06877-0368 (US)

(74) Representative: Hammann, Heinz et al
Boehringer Ingelheim GmbH Binger Strasse 173
55216 Ingelheim am Rhein
55216 Ingelheim am Rhein (DE)


(56) References cited: : 
EP-A2- 1 233 060
 US-A1- 2002 172 991
   
  • CHEN G ET AL: "Kinetic mechanism of the p38-alpha MAP kinase: phosphoryl transfer to synthetic peptides." BIOCHEMISTRY. 29 FEB 2000, vol. 39, no. 8, 29 February 2000 (2000-02-29), pages 2079-2087, XP002407542 ISSN: 0006-2960
  • WARD N E ET AL: "The intrinsic ATPase activity of protein kinase C is catalyzed at the active site of the enzyme." BIOCHEMISTRY. 30 JUN 1992, vol. 31, no. 25, 30 June 1992 (1992-06-30), pages 5905-5911, XP009074947 ISSN: 0006-2960
  • DIPOLO R ET AL: "In squid axons, ATP modulates Na+-Ca2+ exchange by a Ca2+i-dependent phosphorylation." BIOCHIMICA ET BIOPHYSICA ACTA. 12 MAR 1987, vol. 897, no. 3, 12 March 1987 (1987-03-12), pages 347-354, XP009074943 ISSN: 0006-3002
  • PORRELLO K ET AL: "Regulation of reactivated contraction in teleost retinal cone models by calcium and cyclic adenosine monophosphate." THE JOURNAL OF CELL BIOLOGY. JUN 1984, vol. 98, no. 6, June 1984 (1984-06), pages 2230-2238, XP009074942 ISSN: 0021-9525
  • CASSIDY P ET AL: "Irreversible thiophosphorylation and activation of tension in functionally skinned rabbit ileum strips by [35S]ATP gamma S." THE JOURNAL OF BIOLOGICAL CHEMISTRY. 10 NOV 1979, vol. 254, no. 21, 10 November 1979 (1979-11-10), pages 11148-11153, XP002407543 ISSN: 0021-9258
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).