(19)
(11) EP 1 877 043 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
29.05.2013 Bulletin 2013/22

(45) Mention of the grant of the patent:
10.04.2013 Bulletin 2013/15

(21) Application number: 06757650.4

(22) Date of filing: 04.05.2006
(51) International Patent Classification (IPC): 
A61K 31/05(2006.01)
A61P 43/00(2006.01)
A61P 35/04(2006.01)
(86) International application number:
PCT/KR2006/001702
(87) International publication number:
WO 2006/121263 (16.11.2006 Gazette 2006/46)

(54)

USE OF PAEONOL FOR INHIBITING ANGIOGENESIS OR FOR ENHANCING RADIOSENSITIZATION

VERWENDUNG VON PAEONOL ZUR HEMMUNG DER ANGIOGENESE ODER ZUR VERBESSERUNG DER RADIOSENSIBILISIERUNG

UTILISATION DE PAEONOL DANS L'INHIBITION DE L'ANGIOGENESE OU DANS L'AMELIORATION DE LA RADIOSENSIBILISATION


(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

(30) Priority: 06.05.2005 KR 20050038014
06.05.2005 KR 20050038015

(43) Date of publication of application:
16.01.2008 Bulletin 2008/03

(73) Proprietor: AngioLab, Inc.
Yuseong-gu Daejeon 305-509 (KR)

(72) Inventors:
  • KIM, Min-Young
    Yoosung-gu, Taejon 135-727 (KR)
  • LEE, Hee-Suk
    Dongdaemun-gu, Seoul 130-090 (KR)
  • BAE, Ki-Hwan
    Yoosung-gu, Taejon 305-330 (KR)
  • YUN, Yeon-Sook
    Gangnam-gu, Seoul 135-280 (KR)
  • SONG, Jie-Young
    Goyang-si, Gyeoggi-do 411-352 (KR)
  • HAN, Young-Soo
    Buchon-si, Gyeonggi-do 421-220 (KR)

(74) Representative: Allan, James Stewart et al
Murgitroyd & Company Scotland House 165-169 Scotland Street
Glasgow G5 8PL
Glasgow G5 8PL (GB)


(56) References cited: : 
WO-A-2006/056117
CN-A- 1 102 340
CN-A- 1 163 763
US-B2- 6 569 468
WO-A-2006/106350
CN-A- 1 142 338
CN-A- 1 205 232
   
  • DATABASE EMBASE [Online] ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL; February 2005 (2005-02), JI C -Y ET AL: "Effect of paeonol on apoptosis and cell cycle of human colorectal cancer cells as well as prognosis of patients" XP002525100 Database accession no. EMB-2005272436 & CHINESE JOURNAL OF CLINICAL REHABILITATION 200502 CN, vol. 9, no. 6, February 2005 (2005-02), pages 122-124, ISSN: 1671-5926
  • DATABASE MEDLINE [Online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; August 1999 (1999-08), DAI M ET AL: "[Inhibitory effect of paeonol on experimental atherosclerosis in quails]" XP002525101 Database accession no. NLM12205869 & ZHONGGUO ZHONG YAO ZA ZHI = ZHONGGUO ZHONGYAO ZAZHI = CHINA JOURNAL OF CHINESE MATERIA MEDICA AUG 1999, vol. 24, no. 8, August 1999 (1999-08), pages 488-490 , 512, ISSN: 1001-5302
  • DATABASE BIOSIS [Online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1988, SHI L ET AL: "INHIBITORY EFFECTS OF PAEONOL ON EXPERIMENTAL ATHEROSCLEROSIS AND PLATELET AGGREGATION OF RABBIT" XP002525102 Database accession no. PREV198987029841 & ACTA PHARMACOLOGICA SINICA, vol. 9, no. 6, 1988, pages 555-558, ISSN: 0253-9756
  • DATABASE BIOSIS [Online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1979, ARICHI S ET AL: "MOUTAN CORTEX 3. ANTI INFLAMMATORY ACTIVITIES 1" XP002525103 Database accession no. PREV198070011708 & SHOYAKUGAKU ZASSHI, vol. 33, no. 3, 1979, pages 178-184, ISSN: 0037-4377
  • CHANG ET AL.: 'Inhibitory effects of phenolics on xanthine oxidase' ANTICANCER RESEARCH vol. 14, no. 2A, March 1994 - April 1994, pages 501 - 506, XP008123672
  • CHUNG: 'Paeonol promotion of DNA adduct formation and arylamines N-acetyltransferase activity in human colon tumour cells' FOOD AND CHEMICAL TOXICOLOGY vol. 37, 1999, pages 327 - 334, XP008123645
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).