| (84) |
Designated Contracting States: |
|
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE
SI SK TR |
|
Designated Extension States: |
|
AL BA HR MK YU |
| (30) |
Priority: |
03.05.2005 US 677583 P
24.02.2006 US 776847 P
13.03.2006 US 782244 P
17.04.2006 US 792645 P
25.04.2006 US 411003
|
| (43) |
Date of publication of application: |
|
27.02.2008 Bulletin 2008/09 |
| (60) |
Divisional application: |
|
10008795.6 / 2264063 |
|
10014362.7 / 2325199 |
|
10014374.2 / 2325200 |
|
10014375.9 / 2336163 |
| (73) |
Proprietor: AMGEN, INC. |
|
Thousand Oaks, CA 91320 (US) |
|
| (72) |
Inventors: |
|
- PASZTY, Christopher
Ventura, California 93003 (US)
- ROBINSON, Martyn, Kim
Wooburn Green
Buckinghamshire HP10 0JH (GB)
- GRAHAM, Kevin
Thousand Oaks, California 91362 (US)
- HENRY, Alistair, James
Uxbridge Middlesex UB8 2LX (GB)
- HOFFMANN, Kelly, Sue
Newbury Park, California 91320 (US)
- LATHAM, John
Seattle, Washington 98119 (US)
- LAWSON, Alastair
Slough Berkshire SL1 3WE (GB)
- LU, Hsieng, Sen
Westlake Village, California 91362 (US)
- POPPLEWELL, Andy
Slough Berkshire SL1 3WE (GB)
- SHEN, Wenyan
Thousand Oaks, California 91362 (US)
- WINKLER, David
Arlington, Massachusetts 02476-7326 (US)
- WINTERS, Aaron, George
Ventura, California 93001 (US)
|
| (74) |
Representative: Campbell, Patrick John Henry |
|
J A Kemp
14 South Square
Gray's Inn
London WC1R 5JJ
London WC1R 5JJ (GB) |
| (56) |
References cited: :
WO-A-00/32773
WO-A-2005/014650
|
WO-A-2005/003158
US-A- 6 057 421
|
|
| |
|
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- WARMINGTON K ET AL: "Scierostin antagonism in adult rodents, via monoclonal antibody
mediated blockade, increases bone mineral density and implicates sclerostin as a key
regulator of bone mass during adulthood" JOURNAL OF BONE AND MINERAL RESEARCH, vol.
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& JP 04 141095 A (CHEMO SERO THERAPEUT RES INST), 14 May 1992 (1992-05-14)
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vol. 100, no. 2, September 1995 (1995-09), pages 109-114, ISSN: 0895-8017
- SCHWARTZ ANN V ET AL: "Diabetes, fracture, and bone fragility.", CURRENT OSTEOPOROSIS
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