TRANSCRIPTION FACTOR DECOY

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EP 1 892 293 A8

(12)	CORRECTED EUROPEAN PATENT APPLICATION
	published in accordance with Art. 153(4) EPC

(15)	Correction information:
	Corrected version no 1 (W1 A1)

(48)	Corrigendum issued on:
	25.06.2008 Bulletin 2008/26

(43)	Date of publication:
	27.02.2008 Bulletin 2008/09

(21)	Application number: 06757008.5

(22)	Date of filing: 06.06.2006

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International Patent Classification (IPC):

C12N 15/09^(2006.01)
A61P 1/04^(2006.01)
A61P 9/10^(2006.01)
A61P 11/06^(2006.01)
A61P 13/12^(2006.01)
A61P 17/02^(2006.01)
A61P 19/02^(2006.01)
A61P 35/00^(2006.01)
A61P 37/00^(2006.01)
A61P 41/00^(2006.01)
C07H 21/00^(2006.01)

A61K 31/713^(2006.01)
A61P 9/00^(2006.01)
A61P 11/00^(2006.01)
A61P 13/02^(2006.01)
A61P 17/00^(2006.01)
A61P 17/06^(2006.01)
A61P 29/00^(2006.01)
A61P 35/04^(2006.01)
A61P 37/08^(2006.01)
A61P 43/00^(2006.01)

(86)	International application number:
	PCT/JP2006/311268

(87)	International publication number:
	WO 2006/132204 (14.12.2006 Gazette 2006/50)

(84)	Designated Contracting States:
	AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

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Priority:

06.06.2005 JP 2005165477

(71)	Applicant: AnGes MG, Inc.
	Ibaraki-shi, Osaka 567-0085 (JP)

(72)	Inventors:
	GEMBA, Takefumi Kawanishi-shi, Hyogo 666-0014 (JP) UENO, Nobuhiro Takatsuki-shi, Osaka 569-1025 (JP)

(74)	Representative: Gille Hrabal Struck Neidlein Prop Roos
	Patentanwälte Brucknerstrasse 20 40593 Düsseldorf 40593 Düsseldorf (DE)

(54)	TRANSCRIPTION FACTOR DECOY

(57) Double-stranded oligonucleotides useful as decoy oligonucleotides having a high binding ability to a transcription factor and having a reduced cytotoxicity are disclosed. Each of the double-stranded oligonucleotides is formed by hybridization of a sense strand oligonucleotide of the following Formula A:

5'-N(m)-G-Consensus Sequence-C-N(n)-3' (Formula A)

(wherein N(m) is a flanking sequence at the 5'-end, and represents that "N"(s) in the number of m is(are) ligated; N(n) is a flanking sequence at the 3'-end, and represents that "N"(s) in the number of m is(are) ligated; all "N"(s) each independently represent(s) nucleotide A, G, T, C or U; m and n represent each independently an integer of 0 to 20; and Consensus Sequence represents a consensus sequence to which a transcription factor binds)
and an antisense strand oligonucleotide complementary to said sense strand oligonucleotide.