| (19) |
 |
|
(11) |
EP 1 908 851 A8 |
| (12) |
CORRECTED EUROPEAN PATENT APPLICATION |
|
Note: Bibliography reflects the latest situation |
| (15) |
Correction information: |
|
Corrected version no 1 (W1 A2) |
| (48) |
Corrigendum issued on: |
|
15.10.2008 Bulletin 2008/42 |
| (88) |
Date of publication A3: |
|
25.06.2008 Bulletin 2008/26 |
| (43) |
Date of publication: |
|
09.04.2008 Bulletin 2008/15 |
| (22) |
Date of filing: 19.09.2002 |
|
| (51) |
International Patent Classification (IPC):
|
|
| (84) |
Designated Contracting States: |
|
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR |
| (30) |
Priority: |
19.09.2001 US 323510 P
|
| (62) |
Application number of the earlier application in accordance with Art. 76 EPC: |
|
02773461.5 / 1436423 |
| (71) |
Applicants: |
|
- Intergenetics Incorporated
Oklahoma City, OK 73104 (US)
- Oklahoma Medical Research Foundation
Oklahoma City, OK 73104 (US)
|
|
| (72) |
Inventors: |
|
- Ralph, David
Edmund, OK 73034 (US)
- Aston, Christopher
Edmund, OK 73003 (US)
- Jupe, Eldon
Norman, OK 73071 (US)
|
| (74) |
Representative: Dehmel, Albrecht |
|
Dehmel & Bettenhausen
Patentanwälte,
Herzogspitalstrasse 11
80331 München
80331 München (DE) |
|
| |
|
|
|
Remarks: |
|
This application was filed on 19-12-2007 as a divisional application to the application
mentioned under INID code 62. |
|
| (54) |
Genetic analysis for stratification of cancer risk |
(57) The present invention provides new methods for the assessment of cancer risk in the
general population. These methods utilize particular alleles of two or more genes,
in combination, to identify individuals with increased or decreased risk of cancer.
Exemplified is risk assessment for breast cancer in women. In addition, personal history
measures such as age and race are used to further refine the analysis. Using such
methods, it is possible to reallocate healthcare costs in cancer screening to patient
subpopulations at increased cancer risk. It also permits identification of candidates
for cancer prophylactic treatment.