ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESILTLVFIRO..CY..TRBGCZEEHUPLSK....IS..............................JDIM360 Ver 2.15 (14 Jul 2008) - 2999001/01911743CORRECTED EUROPEAN PATENT SPECIFICATIONB8B120130116W172deBibliographieenBibliographyfrBibliographieEP06782403.7200608012008013120110321jaenen200522346220050801JP2013011620130320080416200816201204042012142011092920120404CY20120404FI20120705GR20120804IS20120404LT20120404LV20120404PL20120806PT20120404SE20120404SI20130116201303C07D 207/08 20060101AFI20070419BHEP A61K 31/402 20060101ALI20070419BHEP A61K 31/451 20060101ALI20070419BHEP A61K 31/47 20060101ALI20070419BHEP A61P 5/26 20060101ALI20070419BHEP A61P 7/00 20060101ALI20070419BHEP A61P 7/06 20060101ALI20070419BHEP A61P 9/10 20060101ALI20070419BHEP A61P 15/10 20060101ALI20070419BHEP A61P 15/12 20060101ALI20070419BHEP A61P 19/10 20060101ALI20070419BHEP A61P 25/24 20060101ALI20070419BHEP A61P 25/28 20060101ALI20070419BHEP A61P 35/00 20060101ALI20070419BHEP C07D 207/12 20060101ALI20070419BHEP C07D 211/42 20060101ALI20070419BHEP C07D 215/06 20060101ALI20070419BHEP deCYCLISCHE AMINVERBINDUNGenCYCLIC AMINE COMPOUNDfrCOMPOSÉ D'AMINE CYCLIQUEEP-A1- 1 553 074JP-A- 09 084 596JP-A- 2002 088 073JP-A- 2003 252 854JP-A- 2004 091 486JP-A- 2004 509 072US-A- 3 103 542US-A- 3 639 411US-A- 5 049 577US-A1- 2004 083 559AGARWAL N ET AL: "A diversity oriented synthesis of highly functionalized unsymmetrical biaryls through carbanion induced ring transformation of 2H-pyran-2-ones" TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL LNKD- DOI:10.1016/S0040-4020(02)01066-9, vol. 58, no. 43, 21 October 2002 (2002-10-21), pages 8793-8798, XP004390188 ISSN: 0040-4020RAM V J ET AL: "Carbanion-induced base-catalyzed synthesis of unsymmetrical biaryls from suitably functionalized 2H-pyran-2-ones through ring-transformation reactions" TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL LNKD- DOI:10.1016/S0040-4039(01)01481-2, vol. 42, no. 40, 1 October 2001 (2001-10-01), pages 7127-7129, XP004317908 ISSN: 0040-4039MCINTIRE FLOYD C ET AL: "1-Fluoro-2,4-dinitrobenzene as a quantitative reagent for primary and secondary amines" ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US LNKD- DOI:10.1021/AC60083A050, vol. 25, no. 11, 1 November 1953 (1953-11-01), pages 1757-1758, XP009136567 ISSN: 0003-2700BAXTER E.W. ET AL.: 'Expeditious Synthesis of Azasugars by the Double Reductive Amination of Dicarbonyl Sugars' JOURNAL OF ORGANIC CHEMISTRY vol. 59, no. 11, 1994, pages 3175 - 3185, XP001027683CLARK-LEWIS J.W. AND MORTIMER P.I.: '4-Hydroxypipecolic acid from Acacia species, and its stereoisomers' JOURNAL OF THE CHEMICAL SOCIETY 1961, pages 189 - 201, XP003002175BLAKE J. ET AL.: '3-Pyrrolidinones by intramolecular condensation' JOURNAL OF THE AMERICAN CHEMICAL SOCIETY vol. 86, no. 23, 1964, pages 5293 - 5299, XP003002176BUTLER R. ET AL.: 'Stereoisomeric styryl-substituted pyrrolidines, 3,7-diazabicyclo[3.3.0]octanes and 2-styrylpyrroles from cinnamaldehyde iminium-N-methanide 1,3-dipoles' JOURNAL OF CHEMICAL RESEARCH SYNOPSES no. 2, 1998, pages 82 - 83, XP003002177YANG Q. ET AL.: 'Palladium-Catalyzed Tandem N-Arylation/Carboamination Reactions for the Stereoselective Synthesis of N-Aryl-2-benzyl Pyrrolidines' ORGANIC LETTERS vol. 7, no. 13, 2005, pages 2575 - 2578, XP003002178ELSLAGER E. ET AL.: 'Folate Antagonists. 3. 2,4-Diamino-6-(heterocyclic)quinazolines, a Novel Class of Antimetabolites with Potent Antimalarial and Antibacterial Activity' JOURNAL OF MEDICINAL CHEMISTRY vol. 15, no. 8, 1972, pages 827 - 836, XP000571624YUZEFOVICH L.Y. ET AL.: 'Mechanism of the ring-chain tautomerism of 2,3,3-trimethyl-2-hydroxy-5-pyrrolidinones' KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII no. 5, 1979, pages 616 - 619, XP003002179NOGUE D. ET AL.: 'Two cis ring-fused exo N-aryl heterocycles: 1-phenyl-2-(2,4,6-trimethylphenyl)dechahydr o quinolin-4-one and 1-(4-trifluoromethylphenyl)-2-phenyl decahydroquinolin-4-one' ACTA CRYSTALLOGRAPHICA, SECTION C: CRYSTAL STRUCTURE COMMUNICATIONS vol. C52, no. 1, 1996, pages 207 - 210, XP003002180STANETTY P. ET AL.: 'A Novel Hetero-Diels-Alder Approach towards Perhydro Quinolinoes Bearing an Angular Methyl Group' TETRAHEDRON vol. 54, no. 5/6, 1998, pages 875 - 894, XP00410660920100802YAMAMOTO, Satoshic/o TAKEDA PHARMACEUTICAL COMPANY LIMITED 26-1 Muraoka-Higashi 2-chomeFujisawa Kanagawa 251-0012 JapanJPHASUOKA, Atsushic/o TAKEDA PHARMACEUTICAL COMPANY LIMITED 26-1 Muraoka-Higashi 2-chomeFujisawa Kanagawa 251-0012 JapanJPTakeda Pharmaceutical Company Limited100231971P41643EP1-1, Doshomachi 4-chome Chuo-kuOsaka-shi, Osaka 541-0045JPWright, Robert Gordon McRaeet al100026735Elkington and Fife LLP Prospect House 8 Pembroke RoadSevenoaks Kent TN13 1XRGBATBEBGCHCYCZDEDKEEESFIFRGBGRHUIEISITLILTLULVMCNLPLPTROSESISKTRJP200631555920060801jaWO20070155672007020820070620080416200816