(19)
(11) EP 1 911 757 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
25.05.2011 Bulletin 2011/21

(45) Mention of the grant of the patent:
02.03.2011 Bulletin 2011/09

(21) Application number: 07076124.2

(22) Date of filing: 10.10.2003
(51) International Patent Classification (IPC): 
C07D 405/04(2006.01)
A61P 43/00(2006.01)
C07D 233/84(2006.01)
C07D 335/06(2006.01)
 A61K 31/4164(2006.01)
C07D 409/04(2006.01)
C07D 311/58(2006.01)
C07F 7/18(2006.01)

(54)

Method of preparation of 3-(1,3-Dihydroimidazole-2-thione-1-yl)-chromanes and thiochromanes as dopamine-beta-hydroxylase inhibitors

Verfahren zur Herstellung von 3-(1,3-Dihydroimidazol-2-thion-1-yl)-chromanen und thiochromanen als Dopamin-beta-hydroxylase Inhibitor

Procédé de préparation de 3-(1,3-Dihydroimidazole-2-thione-1-yl)-chromanes et thiochromanes en tant que inhibiteurs de la dopamine-beta-hydroxylase

(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

(30) Priority: 11.10.2002 GB 0223719
18.10.2002 GB 0224306

(43) Date of publication of application:
16.04.2008 Bulletin 2008/16

(62) Application number of the earlier application in accordance with Art. 76 EPC:
03256420.5 / 1408038

(73) Proprietor: Bial-Portela & CA, S.A.
4745-457 S. Mamede do Coronado (PT)

(72) Inventors:
  • Learmonth, David Alexander
    4445-125 Alfena (PT)
  • Soares da Silva, Patricio Manuel Vieira Araujo
    4150-049 Porto (PT)
  • Beliaev, Alexander
    4485-547 Mindelo, Vila do Conde (PT)

(74) Representative: Curtis, Philip Anthony 
A.A. Thornton & Co. 235 High Holborn
London WC1V 7LE
London WC1V 7LE (GB)


(56) References cited: : 
WO-A-95/29165
 US-A- 5 438 150
   
  • GREENE T W; WUTS PETER G M: "PROTECTIVE GROUPS IN ORGANIC SYNTHESIS" 1991, WILEY & SONS , NEW YORK, US , XP002469938 For stability of TBDMS group see pages 77-81 and stability chart page 414
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).