Silyl-protected hydroxymethyl-carbamoylalkyl-ketones as intermediates in the preparation of dopamine-beta-hydroxylase inhibitors

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EP 1 914 233 B8

(12)	CORRECTED EUROPEAN PATENT SPECIFICATION
	Note: Bibliography reflects the latest situation

(15)	Correction information:
	Corrected version no 1 (W1 B1)

(48)	Corrigendum issued on:
	13.04.2011 Bulletin 2011/15

(45)	Mention of the grant of the patent:
	02.03.2011 Bulletin 2011/09

(21)	Application number: 07076122.6

(22)	Date of filing: 10.10.2003

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International Patent Classification (IPC):

C07D 405/04^(2006.01)
A61P 43/00^(2006.01)
C07D 233/84^(2006.01)
C07D 311/58^(2006.01)

A61K 31/4164^(2006.01)
C07D 409/04^(2006.01)
C07F 7/18^(2006.01)

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Silyl-protected hydroxymethyl-carbamoylalkyl-ketones as intermediates in the preparation of dopamine-beta-hydroxylase inhibitors

Silyl-geschützte Hydroxymethyl-carbamoylalkyl-ketone als Intermediate in der Herstellung von Dopamine-beta-hydroxylase inhibitoren

Hydroxyméthyl-carbamoylalkylkétones protégées par des groupements silyls comme intermédiaires dans la préparation d'inhibiteurs de la Dopamine-beta-hydroxylase

(84)	Designated Contracting States:
	AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

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Priority:

11.10.2002 GB 0223719
18.10.2002 GB 0224306

(43)	Date of publication of application:
	23.04.2008 Bulletin 2008/17

(62)	Application number of the earlier application in accordance with Art. 76 EPC:
	03256420.5 / 1408038

(73)	Proprietor: BIAL - Portela & Ca., S.A.
	4745-457 S. Mamede do Coronado (PT)

(72)	Inventors:
	Learmonth, David Alexander 4445-125 Alfena (PT) Soares Da Silva, Patricio Manuel Vieira Araujo 4150-049 Porto (PT) Beliaev, Alexander 4485-547 Mindelo Vila do Conde (PT)

(74)	Representative: Curtis, Philip Anthony et al
	A.A. Thornton & Co. 235 High Holborn London WC1V 7LE London WC1V 7LE (GB)

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References cited: :

WO-A-95/29165

US-A- 5 438 150

ECKARDT WOLF, ISAAC A. KENNEDY, KLAUS HIMMELDIRK, AND IAN D. SPENSER: "5-Hydroxypentane-2,3-dione and 3-amino-1-hydroxypropan-2-one, putative precursors of vitamin B6" CAN. J. CHEM., vol. 75, no. 7, 1997, pages 942-948, XP002471021
GREENE T W, WUTS PETER G M: "PROTECTIVE GROUPS IN ORGANIC SYNTHESIS" 1991, WILEY & SONS , NEW YORK , XP002469938 * page 77 - pages 81,414 *

Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).