(19)
(11) EP 1 925 677 A3

(12) EUROPEAN PATENT APPLICATION

(88) Date of publication A3:
02.07.2008 Bulletin 2008/27

(43) Date of publication A2:
28.05.2008 Bulletin 2008/22

(21) Application number: 07119607.5

(22) Date of filing: 03.07.2003
(51) International Patent Classification (IPC): 
C12Q 1/68(2006.01)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

(30) Priority: 04.07.2002 GB 0215509

(62) Application number of the earlier application in accordance with Art. 76 EPC:
03762612.4 / 1521847

(71) Applicants:
  • Novartis AG
    4056 Basel (CH)

    BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR 
  • Novartis Pharma GmbH
    1235 Vienna (AT)

    AT 

(72) Inventors:
  • Chibout, Salah-Dine
    68720 Tagolsheim (FR)
  • Grenet, Olivier
    68730 Blotzheim (FR)
  • Imbert, Georges
    68220 Buschwiller (FR)
  • Kehren, Jeanne
    68490 Bantzenheim (FR)
  • Stadtler, Frank
    79591 Eimeldingen (DE)
  • Wolfgang, Curt Douglas
    Germantown, MD 20874 (US)

(74) Representative: Bourgarel, Denis Jacques Marie 
Novartis AG Corporate Intellectual Property
4002 Basel
4002 Basel (CH)

   


(54) Marker genes for determining renal toxicity


(57) Methods are disclosed for fast and accurate readout of kidney toxicity before it occurs and before it is demonstrated by histopathology examination. Ultimately this approach shall allow earlier compound selection. The twelve genes identified, namely Calbindin-D28k, KIM-1, OPN, EGF, Clusterin, VEGF, OAT-K1, Aldolase A, Aldolase B, Podocin, Alpha-2u and C4, were grouped and ultimately can be assessed in the form of a kit using PCR, a high throughput technology, in order to characterize and rank new compounds according to their anticipated general kidney toxicity. Also disclosed are methods for identifying agents useful in the treatment of kidney disease, methods for monitoring the efficacy of a treatment for kidney disease and kidney-specific vectors including the sequences of the disclosed genes, and a method for identifying a candidate gene associated with a biological process including kidney function.





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