(19) |
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(11) |
EP 1 925 677 A3 |
(12) |
EUROPEAN PATENT APPLICATION |
(88) |
Date of publication A3: |
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02.07.2008 Bulletin 2008/27 |
(43) |
Date of publication A2: |
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28.05.2008 Bulletin 2008/22 |
(22) |
Date of filing: 03.07.2003 |
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(51) |
International Patent Classification (IPC):
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(84) |
Designated Contracting States: |
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AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR |
(30) |
Priority: |
04.07.2002 GB 0215509
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(62) |
Application number of the earlier application in accordance with Art. 76 EPC: |
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03762612.4 / 1521847 |
(71) |
Applicants: |
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- Novartis AG
4056 Basel (CH)
BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
- Novartis Pharma GmbH
1235 Vienna (AT)
AT
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(72) |
Inventors: |
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- Chibout, Salah-Dine
68720 Tagolsheim (FR)
- Grenet, Olivier
68730 Blotzheim (FR)
- Imbert, Georges
68220 Buschwiller (FR)
- Kehren, Jeanne
68490 Bantzenheim (FR)
- Stadtler, Frank
79591 Eimeldingen (DE)
- Wolfgang, Curt Douglas
Germantown, MD 20874 (US)
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(74) |
Representative: Bourgarel, Denis Jacques Marie |
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Novartis AG
Corporate Intellectual Property 4002 Basel 4002 Basel (CH) |
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(54) |
Marker genes for determining renal toxicity |
(57) Methods are disclosed for fast and accurate readout of kidney toxicity before it
occurs and before it is demonstrated by histopathology examination. Ultimately this
approach shall allow earlier compound selection. The twelve genes identified, namely
Calbindin-D28k, KIM-1, OPN, EGF, Clusterin, VEGF, OAT-K1, Aldolase A, Aldolase B,
Podocin, Alpha-2u and C4, were grouped and ultimately can be assessed in the form
of a kit using PCR, a high throughput technology, in order to characterize and rank
new compounds according to their anticipated general kidney toxicity. Also disclosed
are methods for identifying agents useful in the treatment of kidney disease, methods
for monitoring the efficacy of a treatment for kidney disease and kidney-specific
vectors including the sequences of the disclosed genes, and a method for identifying
a candidate gene associated with a biological process including kidney function.