(19)

(11)

EP 1 926 372 A2

(12)

(88) Date of publication A3: 14.02.2008 (43) Date of publication: 04.06.2008 Bulletin 2008/23 (21) Application number: 06801941.3 (22) Date of filing: 18.08.2006

(51) International Patent Classification (IPC):  A01N 43/04(2006.01) C07H 21/04(2006.01) A61K 31/70(2006.01) (86) International application number: PCT/US2006/032508 (87) International publication number: WO 2007/022474 (22.02.2007 Gazette 2007/08)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 19.08.2005 US 709598 P 01.11.2005 US 732460 P 19.12.2005 US 751593 P 22.02.2006 US 775924 P 02.03.2006 US 779327 P 16.03.2006 US 783801 P 03.04.2006 US 789109 P (71) Applicant: Cylene Pharmaceuticals, Inc. San Diego, CA 92121 (US)

(72) Inventors: DRYGIN, Denis San Diego, CA 92130 (US) MICHELOTTI, Emil San Diego, CA 92126 (US) O'BRIEN, Sean Carlsbad, CA 92009 (US) RICE, William, G. Del Mar, CA 92014 (US) SIDDIQUI-JAIN, Adam San Diego, CA 92122 (US) WHITTEN, Jeffrey, P. Santee, CA 92071 (US) (74) Representative: Roques, Sarah Elizabeth  J.A. Kemp & Co. 14 South Square Gray's Inn London WC1R 5JJ London WC1R 5JJ (GB)