COMPOSITIONS AND METHODS OF USING CHONDROITINASE ABCI MUTANTS

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EP 1 928 490 B8

(12)	CORRECTED EUROPEAN PATENT SPECIFICATION
	Note: Bibliography reflects the latest situation

(15)	Correction information:
	Corrected version no 1 (W1 B1)

(48)	Corrigendum issued on:
	03.10.2012 Bulletin 2012/40

(45)	Mention of the grant of the patent:
	29.08.2012 Bulletin 2012/35

(21)	Application number: 06815505.0

(22)	Date of filing: 26.09.2006

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International Patent Classification (IPC):

C12N 9/00^(2006.01)
C12N 1/20^(2006.01)
C07H 21/04^(2006.01)

C12N 9/88^(2006.01)
C12N 15/00^(2006.01)

(86)	International application number:
	PCT/US2006/037554

(87)	International publication number:
	WO 2007/038548 (05.04.2007 Gazette 2007/14)

(54)	COMPOSITIONS AND METHODS OF USING CHONDROITINASE ABCI MUTANTS ZUSAMMENSETZUNGEN UND VERFAHREN ZUR VERWENDUNG VON CHONDROITINASE-ABCI-MUTANTEN COMPOSITIONS ET PROCEDES D'UTILISATION DE MUTANTS DES CHONDROITINASES ABCI

(84)	Designated Contracting States:
	AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
	Designated Extension States:
	AL BA HR MK RS

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Priority:

26.09.2005 US 720628 P

(43)	Date of publication of application:
	11.06.2008 Bulletin 2008/24

(73)	Proprietor: Acorda Therapeutics, Inc.
	Ardsley, NY 10502 (US)

(72)	Inventors:
	CAGGIANO, Anthony, O. New York 10538 (US) IACI, Jennifer New Jersey 07005 (US) VECCHIONE, Andrea New York 10552 (US) MARKENSOHN, Elizabeth New Jersey 07836-9506 (US)

(74)	Representative: Ouzman, Beverley Nicola Claire
	Murgitroyd & Company Scotland House 165-169 Scotland Street Glasgow G5 8PL Glasgow G5 8PL (GB)

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References cited: :

WO-A2-2004/103299

WO-A2-2005/087920

HUANG W ET AL: "Crystal Structure of Proteus vulgaris Chondroitin Sulfate ABC Lyase I at 1.9A Resolution" JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, vol. 328, no. 3, 2 May 2003 (2003-05-02), pages 623-634, XP004454197 ISSN: 0022-2836
PRABHAKAR V ET AL: "Biochemical characterization of the chondroitinase ABC I active site" BIOCHEMICAL JOURNAL, THE BIOCHEMICAL SOCIETY, LONDON, GB, vol. 390, no. Part 2, 1 September 2005 (2005-09-01), pages 395-405, XP002551441 ISSN: 0264-6021 [retrieved on 2005-08-23]
SATO N. ET AL.: 'Cloning and expression in Escherichia coli of the gene encoding the Proteus vulgaris ABC lyase' APPL MICROBIOL BIOTECHNOL. vol. 41, no. 1, March 1994, pages 39 - 46, XP008107546
DATABASE GENPEPT [Online] 15 August 2003 XP003024161 Database accession no. P59807
CAGGIANO A.O. ET AL.: 'Chondroitinase ABCI improves locomotion and bladder function following contusion injury of the rat spinal cord' J NEUROTRAUMA. vol. 22, no. 2, February 2005, pages 226 - 239, XP009095122

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