(19)

(11)

EP 1 928 863 A2

(12)

(88) Date of publication A3: 01.11.2007 (43) Date of publication: 11.06.2008 Bulletin 2008/24 (21) Application number: 06790193.4 (22) Date of filing: 06.09.2006

(51) International Patent Classification (IPC):  C07D 405/12(2006.01) A61K 31/44(2006.01) A61K 9/00(2006.01) C07D 405/14(2006.01) C07D 213/75(2006.01) A61K 9/20(2006.01) (86) International application number: PCT/US2006/034813 (87) International publication number: WO 2007/030589 (15.03.2007 Gazette 2007/11)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 09.09.2005 US 715417 P (71) Applicant: Wyeth Madison, NJ 07940 (US)

(72) Inventors: GHOSH, Krishnendu Sparkill, NY 10976 (US) NAGI, Arwinder, S. Thiells, NY 10984 (US) PAN, Xiaohong Highland Mills, New York 10930 (US) LIN, Melissa Wanaque, NY 07465 (US) LINBERG, Leonid Upper Saddle River, New Jersey 07458 (US) CAI, Ping New City, NY 10956 (US) BROWNE, Eric N. C.. Pierrefonds, Québec (CA) BERNATCHEZ, Michel Montréal, Quebec, H1H 1C6 (CA) LANKAU, Mark Dollard Des Ormeaux, Québec H9A 1V9 (CA) RAJE, Sangeeta Audubon, PA 19403 (US) (74) Representative: Talbott, Dawn Jacqueline  Wyeth Pharmaceuticals, Huntercombe Lane South, Taplow Maidenhead, Berkshire SL6 0PH Maidenhead, Berkshire SL6 0PH (GB)